What is APDS?
APDS is a rare, inherited disease*
- In people without APDS, the PI3K delta pathway regulates the development, growth, and division of white blood cells (made up of B and T cells). These white blood cells can help the body fight off infections. When the PI3K delta pathway is working properly, there is a healthy balance of immature and functional cells
- In people with APDS, a genetic variant causes the PI3K delta pathway to be hyperactive. This means the development of B and T cells can be altered and create an imbalance of immature and functional cells. This makes it difficult for the body to fight infections and is thought to cause APDS symptoms
APDS, activated PI3K delta syndrome.
*APDS is a primary immunodeficiency, also known as an inborn error of immunity (or IEI).
*APDS is a primary immunodeficiency, also known as an inborn error of immunity (or IEI).
How APDS could affect you
People with APDS can suffer from a wide range of signs and symptoms.
APDS is a progressive disease, which means it may continue to develop and worsen over time. Part of that progression could lead to permanent, life-threatening organ damage or lymphoma (a type of blood cancer that affects the lymph nodes).
A genetic test can provide a definitive diagnosis of APDS, so it’s important to test as soon as possible. Because APDS can be genetic, family members may also be affected.
Living with APDS
Until now, available therapies have only treated the symptoms of APDS, not the source of the disease.
Joenja works to treat APDS at the source of the imbalance in your immune system caused by PI3K delta hyperactivity.
How Joenja Works
Explore information about Joenja and how it works.
Joenja Results
See the results from the clinical study of Joenja in patients with APDS.
How APDS could affect you
People with APDS can suffer from a wide range of signs and symptoms.
APDS is a progressive disease, which means it may continue to develop and worsen over time. Part of that progression could lead to permanent, life-threatening organ damage or lymphoma (a type of blood cancer that affects the lymph nodes).
A genetic test can provide a definitive diagnosis of APDS, so it’s important to test as soon as possible. Because APDS can be genetic, family members may also be affected.
Living with APDS
Until now, available therapies have only treated the symptoms of APDS, not the source of the disease.
Joenja works to treat APDS at the source of the imbalance in your immune system caused by PI3K delta hyperactivity.
How Joenja Works
Explore information about Joenja and how it works.
Joenja Results
See the results from the clinical study of Joenja in patients with APDS.
